Structural, optical, and magnetic properties of nanostructured Ag-substituted Co-Zn ferrites: insights on anticancer and antiproliferative activities

Magnetic spinel ferrite nanoparticles possess high scientific attention for the researchers attributed to its broad area biomedicine purposes, comprising cancer magnetic hyperthermia and targeted drug delivery. Herein, we report ultrasound irritation assisted sol–gel method Zn0.5Co0.5-xAg2xFe2O4 (x = 0.00, 0.10, 0.20, 0.30) (NPs) synthesis. The Rietveld refinement patterns revealed successful synthesis of cubic structure crystallite size ranged from 14.1 nm 18.4 nm. Also, optical band gap decreased 2.39 eV Co-Zn 2.20 Zn0.5Co0.2Ag0.6Fe2O4 sample. Electron paramagnetic resonance spectroscopy was used study ferromagnetic characteristics samples. field increased 2512.2 Gauss sample 2834.8 sample, while line width 2401.3 1990.1 Gauss. saturation reduced 45.68 emu.g−1 pristine Zn0.5Co0.5Fe2O4 22.20 Furthermore, cytotoxicity NPs against human breast MCF-7, HepG2 liver cancer, LoVo colorectal cells examined. on previous cell lines resulted in inhibition growth estimated by MTT assay. exposure HepG2, 24hs proved a significant apoptotic activity induction p53 gene expression caspase antiproliferative amelioration MMP-2 Bcl-2 expression.